A source told ESPN the team is “cautiously optimistic” that Miller was able to avoid serious damage but will have to see what further tests reveal.
Miller suffered the injury with less than three minutes remaining in the first half when he appeared to get rolled up on a first-and-10 play at the Bills’ 16-yard line. He quickly went to a knee and spent a couple of minutes talking to trainers on the field. He spent several minutes in the medical tent on the sideline before being carted off and taken to the locker room.
Detroit went on to score a touchdown on the drive before Bills kicker Tyler Bass made a 47-yard field goal for a 17-14 lead at halftime.
Miller is in his first year with the Bills and 12th in the NFL. He leads the team in sacks with eight. He had one tackle and one quarterback hit before leaving the game. Miller entered Week 12 ranked second in the NFL with 37 pressures, trailing only Micah Parsons (44).
The injury comes at a tough time for a thin Bills defensive end group. Both Greg Rousseau and A.J. Epenesa, the team’s top pass-rushers after Miller, are inactive with ankle injuries. The remaining defensive ends active for the Bills are Shaq Lawson, Boogie Basham and practice squad player Mike Love, who was elevated for the game.
ESPN’s Jeremy Fowler contributed to this report.